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In CRPC, AR signaling upregulates inhibitory immune checkpoints (e.g., B7-H3) and proinflammatory cytokines (e.g., IL-6, TNF-), which recruit immunosuppressive cells and suppress T-cell function
Blood-brain barrier penetration after peripheral administration needs quantification via CSF sampling in primate models before human trials would be justifiable
PubMed , Life , vol
Studies on animal models showed that epithalon can reduce and prevent cancer development
The pharmacokinetic groundwork came from a Phase 1b trial studying cagrilintide alongside semaglutide 2.4 mg
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