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Men and Women: Colorectal cancer risk: Elevated at 12%-20% Recommend colonoscopy every 1-2 years starting at age 20-25 Gastric cancer risk: Not well established Consider upper endoscopy every 3-5 years beginning at Permanent link to this article: ICARE Newsletter Winter 2020 Lynch Syndrome Cancer Risks Across Genes ICARE Newsletter Winter 2020 Lynch Syndrome Cancer Risks Across Genes A worldwide study reporting on cancer risks among individuals with mutations in Lynch syndrome genes showed that there are substantial differences in cancer risks across the various genes.1 Specifically, the risk for colorectal cancer in those with MLH1, MSH2, and MSH6 mutations was substantially higher than what was seen for those with PMS2 mutations

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Springer, Cham Ray A, Christian JA, Mosso MB, Park E, Wegner W, Willig KI, Barth AL (2023) Quantitative fluorescence analysis reveals dendrite-specific thalamocortical plasticity in L5 pyramidal neurons during learning

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