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Paats MS, Bergen IM, Hoogsteden HC, van der Eerden MM, Hendriks RW

Schizophr Bull Open

The gene CYP19A1 , identified in an OCT perturb-seq screen, was associated with increased tumor PD-L1 levels, potentially through concomitant decrease of TGF- in the TME and upregulation of activating receptor NKG2D on NK cells during CYP19A1 inhibiton [40, 122, 124]