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Conclusion By focusing on the ROS-related PIPN mechanism, both antioxidant drugs (e.g., small molecular drugs, traditional medicines/active ingredients) and tailor-made nanosystems (e.g., tumor-targeting Pt nanosystems and anti-ROS nanosystems) have demonstrated to be effective in the prevention and treatment of PIPN
This primarily stems from internal differences, like the amount of intrinsic factor released in the stomach or genetic defects (much like an MTHFR mutation)
A push focuses more directly on glutathione
10.1016/j.lfs.2016.02.029 8 BarisicI.BalenovicD.KlicekR.RadicB.NikitovicB.DrmicD.et al (2013)
This comprehensive strategy can lead to symptom alleviation and substantial improvements in gastrointestinal well-being, potentially marking a significant advance in the treatment of these challenging conditions
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