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Key differences in bioavailability: Prescription injections: High bioavailability due to direct delivery into the bloodstream OTC oral supplements: Variable bioavailability due to gastrointestinal absorption factors Understanding the differences between prescription B12 injections and OTC supplements helps healthcare providers tailor treatments

The bioavailability difference only matters for oral, nasal, and topical routes of administration

[1] Primarily, the l-carnitine supplements rises the levels of osteoclasts in serum