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The release of sonic hedgehog (SHH) by astrocytes acts on ECs to modulate TJ protein expression and maintain BBB integrity (Daneman and Prat, 2015

The gut-brain axis response, including improvements in fatigue and cognitive clarity that many patients attribute to gut inflammation, often follows several weeks later

By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan

Nothing herein should be interpreted as medical claims, treatment recommendations, or diagnostic guidance

This makes it an appealing option for patients who want to avoid the discomfort and downtime of surgery while still achieving significant fat loss