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Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide
Y.FraserM.LiW.McanullaC.et al
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I strongly caution against this approach
Toxicology of the exocrine pancreas
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