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Ong and Ramasamy 2018)
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Moreover, at moderate levels, ROS oxidatively modifies KEAP1, thereby activating the NRF2 pathway, which induces the transcription of antioxidant genes such as SOD2, GPX1, and HO-1, establishing a defense against oxidative stress in granulosa cells [236]
There have been rare reports , so caution is advised in patients with a history of pancreatitis
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