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Unfortunately, these antibodies arent magic bullets against IBDs
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These progress to vesicles and bullae, eventually developing into the hallmark full-thickness necrosis, detachment, and skin sloughing [49, 51]
In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling
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