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The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

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The importance of tirzepatides action on the GIPR in adipocytes to the medications ability to promote loss of excess adiposity has not been fully elucidated, and further research is needed

Gao, M., Monian, P., Quadri, N., Ramasamy, R

It is non-toxic, non-irritating, and suitable for most skin types, including sensitive skin