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The same set of experiments was conducted for GSSSG-pretreated HGF as a control and results indicated a nearly negligible preventive-effect on HGF nitration (Figure 2c), consistent with the earlier observation that GSSSG treatment barely enhanced HGF-c-met interaction before and after exposure to peroxynitrite (see again Figure 1e, bars 47 and bars 47 )
The most severe risks include promoting the growth of existing cancers, severe hypoglycemia (low blood sugar), and acromegaly (abnormal bone and organ growth)
The combination of high disease burden and growing awareness of effective treatments drives demand for GLP-1 receptor agonists
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