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The shift of tryptophan metabolism towards the kynurenine pathway is also related to increased oxidative stress and is a relevant mechanism involved in MDD
PMID 23920160
In 2023, these states spent the most on GLP-1 weight loss drugs (in millions), in descending order: Texas with $6 billion
Just as we would not prescribe a psychiatric medication without behavioral support, we should not prescribe a medication that reshapes reward circuitry without also helping patients build the habits, coping skills, and expectations that fit their changing brain
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