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The outer thigh usually has the least vascular area, and hence provides the least chance of bruising
In DR, advanced glycation end-products (AGEs), products of hyperglycemia, interact with endothelial cells to stimulate VEGF production, which increases endothelial permeability by destabilizing TJs and promoting the degradation of GDNF, thus impairing barrier function [160]
The TSA makes allowances for "medically necessary" ice packs "in reasonable quantities" regardless of their physical state
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Blundell J, Finlayson G, Axelsen M, Flint A, Gibbons C, Kvist T, Hjerpsted JB (2017) Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity
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