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Kothare PA, Soon DKW, Linnebjerg H, Park S, Chan C, Yeo A, et al
& Rosenbloom, C
Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe/ mice
In the Phase 3 TRIUMPH-4 trial (68 weeks), Retatrutide produced average weight loss of 28.7% at the 12mg dose
The coefficient of variation for orforglipron plasma exposure (AUC and Cmax) across Phase 1 studies was moderate and consistent with typical oral small-molecule drugs, whereas oral semaglutide shows substantially higher variability due to the sensitivity of SNAC-mediated gastric absorption to physiological factors including gastric pH, motility, and volume
