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Evidence boundary The largest Phase 2b trial used oral dosing for 24 weeks and did not show statistically significant weight loss versus placebo
Wegovy (semaglutide) is an FDA-approved prescription medication used for chronic weight management in adults with obesity or excess weight
Weight loss can be seen within 30 days when combined with proper diet and exercise
IV and short-duration oral trials METAOD001-004 enrolled smaller groups of healthy or obese men with single doses or 1-week dosing across IV (25-400 mcg/kg) and oral (9-54 mg) routes
Among fat loss peptides specifically, AOD 9604 stands out for having the most extensive human safety data from controlled trials
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