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Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation
Rieg, T
The key consideration is understanding how both substances work in your body and recognising that their combined effects may be unpredictable or amplified in certain circumstances
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The buffer type and concentration (molarity) further influence how quickly or slowly degradation occurs
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