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Rarely, hypersensitivity reactions can occur, for instance, urticaria (hives) or other allergic-type reactions have been reported in isolated cases

Samms RJ, et al

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This is because nearly all national governments, except for the U.S., negotiate the price of prescription medications, rather than allowing drug companies to charge whatever they deem best for their shareholders

Consequently, caution should be exercised when interpreting findings from large EHR studies