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Administration of CB-1158 (a small molecule inhibitor of arginase) can slow tumor growth rates, block myeloid cell-mediated suppression of T-cell proliferation, and increase the number of tumor-infiltrating CD8 + T cells and NK cells in mouse models of multiple tumors
We also observed an increase in the 18 kDa translocator protein TSPO, which is a mitochondrial cholesterol-binding protein and upregulated in microglia during inflammatory activation associated with neurodegeneration (Fig
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