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The reduced incretin effect in type 2 diabetic patients is much more closely related to the losses in insulinotropic activity of GIP, which are typical of this condition, and less so to those related to GLP-1 [64]
Losing weight in this way is immoral without the oversight of an IRB, and no IRB would allow such an obvious conflict of interest, where the subject gains significant health improvements in exchange for participating
6.4 Postprandial Lipids After 3 weeks of treatment with liraglutide 1.8 mg or placebo in subjects with type 2 diabetes, postprandial levels of triglyceride and apolipoprotein B48 (a structural lipoprotein in chylomicrons, which are secreted following ingestion of lipids and used as a marker of lipid uptake from the gastrointestinal tract) were measured following a standardised fat-rich meal [39]
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Igarashi A, et al
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