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The spinal cord was carefully removed by laminectomy, postfixed for 4 h in 4% PFA and transferred into 30% sucrose overnight for cryoprotection
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Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem
Your healthcare provider will work with you closely to adjust your dose gradually over time and reduce the potential risk of side effects
