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This challenge is further compounded by patient heterogeneity, including differences in genetic background, lifestyle, and disease progression, all of which influence treatment response

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Wegovy is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for weight management in adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities

People who experienced significant wearing-off on semaglutide often find the effect more noticeable after switching to tirzepatide, not because tirzepatide is less effective, but because its shorter half-life creates a wider gap between peak and trough levels

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