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This included circumvention of the complex downhill syndrome, as well as a sudden decrease of blood supply, decreased NO levels in the inferior caval vein tissue, an immediate heavy loss of endothelial cells from the vascular wall, a lower eNOS production ability (Rangan and Bulkley, 1993
Permanent treatment discontinuation occurred in 73 participants (10%), similarly across groups, mostly due to adverse events (30 participants, 4%)
The difference in efficacy between these two doses is modest, but the difference in side effects can be meaningful for some individuals
W.McKennaZ
In 2012, Li et al
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