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Int J Colorectal Dis 33(2):131139

The antihyperglycaemic effect starts after the first dose and is sustained throughout the once-weekly dosing interval, as a result of the prolonged half-life of 4.7 days

[33] and Abd-Elkareem et al

Overall, it was found that berberine improved clinical outcomes and shortened the duration of diarrhea compared to control interventions with no serious adverse events reported

Similarly, Lonborg et al