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1,2 It usually appears during dose increases and improves with continued treatment

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In the liver as well as in other tissues, scientists consider growth hormone to stick to its receptor to promote IGF-1 secretion and synthesis

Additionally, these medications suppress glucagon secretion from pancreatic alpha cells, which helps prevent excessive glucose production by the liver

While meta-analyses of randomized controlled trials suggest a potentially increased risk of biliary diseases with DPP-4 inhibitors globally [13, 30], the absolute risk in Japanese populations appears unknown