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Most patients benefit from continuing some form of GLP-1 or GIP therapy to maintain long-term results
In 2026, ADA/EASD guidance continues to emphasize GLP-1based therapy for many people with type 2 diabetes, especially when weight control is important, or theres a risk of heart or kidney problems
Treat eating as a scheduled activity rather than waiting for hunger that may never come
Options for switching include moving from injectable to oral or sublingual semaglutide , transitioning between tirzepatide and semaglutide , or considering a dose conversion to a different GLP-1 agonist at a lower relative dose
These larger molecules show reduced renal clearance as well as being DPP-4 resistant
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