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We also observed that weight loss induced by semaglutide, or dietary intervention improves skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) efficiency in diet-induced obese (DIO) mice, consistent with tighter ATP to O 2 (P/O) coupling (15, 17)
They are especially effective for those with weight-related health conditions, offering a safe and proven solution for long-term weight management
Int J Androl 1984;7:484-94
The mechanism is intriguing: by mimicking the GLP-1 hormone naturally produced in the body, semaglutide slows down gastric emptying and influences the central nervous system to reduce hunger and increase feelings of fullness
Therefore, it is better to mainly reduce fat without significant reducing muscle mass when weight loss is achieved
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