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Weeks 1-4: tirzepatide only phase During the tirzepatide-only phase, the primary change is appetite reduction

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Two practical points follow

It is a well-tolerated compound with a clean safety profile and a genuinely interesting mechanism that, so far, has produced results in humans that fall short of what animal models predicted

A large study of 2,000 obese adults found that participants using semaglutide combined with diet and exercise lost up to 15-20% of their body weight after 68 weeks