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Retatrutide is a novel triple-agonist peptide engineered to activate three metabolic hormone receptors simultaneously: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) Glucagon receptors Unlike single or dual incretin therapies, retatrutide is designed to produce a broader metabolic response by influencing appetite regulation, energy expenditure, and glucose metabolism all at once

Eating disorder risk For individuals with a history of disordered eating, GLP-1-induced appetite suppression can unintentionally reinforce restriction or trigger old patterns

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Provide ways to lower medication costs Many patients have to take GLP-1s long-term, especially if they want sustained effects