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Reviewed PARP1 hyperactivation as a driver of NAD+ depletion in DNA damage models and the basis for NAD+ supplementation research in premature ageing syndromes
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Hohlfeld, R., Dornmair, K., Meinl, E
This M1 polarization leads to increased expression of pro-inflammatory markers (such as CD80 and CD86) and cytokines (like IL-1, IL-6, and IL-12), while reducing levels of immunosuppressive cytokines such as IL-10
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