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* Correspondence: Prakash Shankaran, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Vials stored at refrigeration temperature (28C) rather than frozen have shorter shelf lives approximately 36 months because residual moisture content below 5% still permits slow degradation

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While MT-1 is selective for the MC1R receptor, MT-2s cyclic structure gives it structural compatibility with multiple melanocortin receptor subtypes, including MC1R, MC3R, MC4R, and MC5R