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Once formed from dietary methionine, homocysteine can be catabolized to cysteine via the transsulfuration pathway or re-methylated to methionine ( Figure 4 )

The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network

4 The bodys metabolic rate increases during high-intensity exercise, increasing the demand for oxygen to produce muscle energy

Rost and Rapoport cynically compiled the GSH/GSSG potentials measured up to 1964: The E m7 values ranged from 350 to +40 mV depending on the methodology applied (Rost and Rapoport, 1964)