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Gubellini P, Pisani A, Centonze D, Bernardi G, Calabresi P (2004)
Ghati et al., 2021
Because of the high heterogeneity of RA, researchers realize that the current efforts are far from enough to recommend specific DMARDs for individual patients
For example, GPER activation promotes AMPK phosphorylation, increasing AMPK activity, increasing fatty acid oxidation, and suppressing fatty acid synthesis to regulate cellular metabolism [59]
The peptide inhibited hyperglycemia-induced epithelial-mesenchymal transition (EMT) and downregulated fibrosis-related genes, preventing the subretinal fibrosis that represents end-stage proliferative diabetic retinopathy
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