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Clinical trial data for FDA-approved branded semaglutide showed meaningful weight changes beginning in weeks 4 through 12, with continued results accumulating over a 68-week period

For instance, Novo Nordisks CagriSema, a combination of semaglutide and cagrilintide, has shown superior results in lowering blood glucose and promoting weight loss compared to semaglutide alone

Kidney and liver function As semaglutide binds strongly to albumin and is cleared slowly, any liver or kidney disease may influence clearance time

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Some GLP-1 receptor agonists have also demonstrated cardiovascular benefits in clinical trials, though this varies between agents