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RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation
Given the importance of quality sleep for metabolic health, recovery, and appetite regulation, this effect may contribute to overall protocol success beyond direct tissue healing benefits
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