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A stronger barrier also allows for better retention of nutrients, which is helpful for dry or sensitive areas

doi: 10.34172/hpp.2020.18 2 ShamoonHDuffyHFleischerNEngelSSaengerPStrelzynMet al

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Understanding stability and expiration is equally important

First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death