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A GLP-1/GIP dual receptor agonist DA4-JC effectively attenuates cognitive impairment and pathology in the APP/PS1/Tau model of alzheimers disease

This strategy holds promise for developing oral peptide therapeutics with enhanced bioavailability and therapeutic efficacy, exemplified by the success of biotinylated GLP-1 analogues in improving glucose control

As the same doses were used across the two studies, later publications may clarify whether titration played a role in adverse events and differing discontinuation rates, or whether this is primarily due to differences in tolerability

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