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[2] [5] High doses of acetaminophen are known to deplete endogenous glutathione stores, particularly in the liver, which may increase the risk of toxicity
in cell assays it reaches nanomolar activity and maintains stability in plasma and liver microsomes, and in animal models it inhibits tumor growth at tolerated doses with suitable formulations (77)
HNF4A regulated APEH deficiency promotes UPR activation in diabetic kidney disease
a true vitamin B12 overdose is extremely rare
Liver biopsy data showed ~30% tissue area occupied by sphingomyelin at baseline, with ~90% clearance after 0.5-1Y of olipudase alfa
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