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The approval was backed by results of a prespecified exploratory subgroup analysis by MMR status in the DUO-E Phase III trial where Imfinzi plus chemotherapy followed by Imfinzi monotherapy reduced the risk of disease progression or death by 58% versus chemo alone

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Anna Brancato, University of Palermo, Italy Updates Copyright 2019 Jrvinen, Laine, Tikkanen and Castrn

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This is the most popular split dosing schedule and likely the best compromise between side effect reduction and efficacy preservation