Ethics declarations Competing interests The authors are employees of nference, inc., which conducts research collaborations with various biopharmaceutical companies whose therapeutic products are included in this study
In VSMC-specific ANK knockout mice, the levels of citrate and acetyl-CoA increased significantly, which in turn promoted the acetylation of histones H3K23ac, H3K27ac, and H4K5ac, inducing the mRNA expression of pro-inflammatory factors (CCL2, IL-6, and MMP9) and the pro-inflammatory phenotype conversion of VSMCs
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The team focused on two areas in the brain stem where GLP-1 drugs have a big effect