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Tirzepatides 5 mg, 10 mg, and 15 mg doses showed A1C reductions of 2.01, 2.24 and 2.30, respectively, surpassing semaglutides 1.86 reduction at the 1 mg dose
For diabetes treatment, NICE recommends continuing GLP-1 therapy only if HbA1c has fallen by at least 11 mmol/mol (1%) and weight has reduced by at least 3% after approximately 6 months, unless there are individual clinical reasons to continue
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease
44 Semaglutide in Obese or Overweight Patients without Type 2 Diabetes Xie et al performed a systematic review of studies conducted in populations with OAO, but without T2DM, and indicated that semaglutide 2.4 mg had a significant advantage in decreasing body mass and HbA1c level, but the incidence of total AEs was also the highest and could cause hypoglycemia