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Excessive burden of ROS, failure of clearance mechanisms and even lack of antioxidants may lead to the accumulation of ROS and to oxidative stress [40], which are associated with genetic damage and breast cancer onset [61,62,63,64,65]

Finally, NAC is mainly used to treat acetaminophen poisoning and as a mucolytic agent [437]

Landmark trials, including CREDENCE, DAPA-CKD, EMPA-KIDNEY, and FLOW, have demonstrated their efficacy in preserving kidney function and reducing adverse outcomes

Severe vitamin E deficiency has been associated with specific genetic defects affecting the hepatic trafficking of -tocopherol by -tocopherol transfer protein (-TTP) and transport in lipoproteins (apolipoprotein B)

In a variety of cell lines, GSNO treatment combined with a MEK inhibitor was shown to inhibit the proliferation and invasive phenotype of the cells (Furuhashi et al., 2012)