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In the intestine and liver, curcumin is readily conjugated to form curcumin glucuronide and curcumin sulfate or, alternately, reduced to tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin ( Figure 2 ) (4)

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Also, remember: If your tirzepatide headache gets worse instead of getting better or is associated with alarming symptoms like sudden severe pain, vision changes, weakness, confusion, or fever, seek emergency medical attention