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The medication acts on receptors in the brain to reduce hunger signals and increase satiety, while simultaneously slowing the rate at which food leaves the stomach

Across all six studies, the safety findings were consistent: no serious adverse events, no immunogenic responses, no changes in IGF-1, no glucose or insulin disruption

Abbreviations T2DM: Type 2 diabetes mellitus GLP-1RAs: Glucagon-like peptide-1 receptor agonists GIP: Glucose-dependent insulinotropic peptide hsCRP: High-sensitivity C-reactive protein IL: Interleukin MD: Mean difference CI: Confidence intervals SE: Standard error MASLD: Metabolic dysfunction-associated steatotic liver disease MCP-1: Monocyte chemoattractant protein-1 References NCD Risk Factor Collaboration (NCD-RisC)