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Conditions that result in red blood cell destruction, releasing a massive amount of free hemoglobin into the bloodstream, include: Infections by bacteria, parasites (malaria), and influenza virus [23]

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The absorption of non-heme iron, from the lumen of the small intestine, requires that the dietary iron, which is predominantly in the oxidized state (Fe 3+ ), be reduced to the ferrous (Fe 2+ ) state