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Finally, recent studies have suggested that the oxidation of lipids (such as polyunsaturated fatty acids and cholesterol) generates electrophilic compounds that modify Lys residues in SOD1, inducing its aggregation (Dantas et al., 2020)

The lubricating layer (PP), containing phosphatidylserine (PS), reduces frictional stress, while the regenerative layer (GM/GV), composed of gelatin methacrylate (GM) and vanillin-modified gelatin (GV), scavenges ROS and mitigates AGEs-induced collagen disorder deposition