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As the process continues, dehydration and rearrangement leads to cross-links between adjacent proteins, resulting in protein aggregates, advanced glycation end products (AGE's) and increased oxidative stress (glycoxidation)

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The workspace should be clean and free from drafts or contaminants

Lastly, utilizing RNAScope in situ hybridization in the lower intestines of mice, we observed that GLP-1 cells expressed generic markers of secretory cells such as Snap25 and Nefm , but neither synaptic markers such as Syn1 and Nrxn2 , nor glutamatergic markers such as Slc17a7

10.2337/diabetes.50.11.2497 19