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If you review the potential side effects and drug interactions, you can understand why the risk of the medication combination could be too high for some patients

Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit potential risk of hypoglycemia

Chin Med J 132(1):106108 Hu Y, Ma X (2021) Icariin treatment protects against gentamicin-induced ototoxicity via activation of the AMPK-SIRT3 pathway

Chem Eng J 487:150612 Sun Z, Zhang B, Tu H, Pan C, Chai Y, Chen W (2024) Advances in colorimetric biosensors of exosomes: novel approaches based on natural enzymes and nanozymes