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Bariatric surgery may be considered for eligible adults typically those with a BMI of 40 kg/m or above, or 35 kg/m or above with significant obesity-related comorbidities following engagement with Tier 3 specialist weight management services, in line with NICE guidance
[4] [5] Such development typically takes many years and must meet rigorous regulatory standards set by the MHRA and European Medicines Agency (EMA) before any product could be approved for patient use
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Semaglutide treatment commenced at 0.25 mg per week for the initial 4 weeks using a pre-filled pen injector, with a fixed-dose escalation every 4 weeks until reaching the maintenance dose of 2.4 mg by week 16 (lower maintenance doses allowed if 2.4 mg was intolerable for participants)
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