Among our participants, nausea incidence was comparable to the lowest maintenance dose of tirzepatide, while fewer reported constipation or diarrhoea ( In a randomized controlled trial invastigating the efficacy of subcutaneous semaglutide injections at a dose of 2.4 mg weekly for obesity treatment, participants experienced an average weight loss of 15% and a BMI reduction by an average of 5.5 kg/m after 68 weeks ( In the PIONEER 1 study ( Additionally, in the OASIS 1 trial ( According to our data and published data on other medications, we can indirectly infer that oral semaglutide at a dose of 14 mg is associated with less weight loss and a smaller reduction in BMI compared to tirzepatide at all maintenance doses, subcutaneous semaglutide at 2.4 mg weekly, and oral semaglutide at 50 mg daily
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hypertension, type 2 DM, dyslipidemia) A meta-analysis of 22 trials involving over 17,000 patients determined that 50.2% and 17.5% of patients treated with GLP-1RAs (exenatide, semaglutide & liraglutide) experienced a weight loss of 5% and 10% compared to placebo, and that patients without type 2 diabetes achieved a significantly greater weight loss compared to those with diabetes (Vosoughi et al, 2022)
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