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The apoptosis inducers, such as fraxetin and 4-hydroxy-2(3H)-benzoxazolone have been shown to induce HSC apoptosis in many animal experiments

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Landzberg M, Murphy D, Davidson W, Jarcho J, Krumholz H , Mayer J, Mee R, Sahn D, Van Hare G, Webb G, Williams R

doi:10.1016/j.eprac.2022.03.010 10European Association for the Study of the Liver (EASL)

In mice, the benefits of FOXO4-DRI continued to develop after the treatment period ended, as tissue remodeling and functional recovery are ongoing processes (Baar et al., 2017)